Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reduced vertebral bone density in hypercalciuric nephrolithiasis.

F Pietschmann1, N A Breslau, C Y Pak

  • 1Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of medical approach in the management of stone disease.

International journal of urology : official journal of the Japanese Urological Association·2013
Same author

Sustained-release sodium fluoride in the treatment of the elderly with established osteoporosis.

Archives of internal medicine·2001
Same author

Biochemical profile of idiopathic uric acid nephrolithiasis.

Kidney international·2001
Same author

The effect of calcium citrate on bone density in the early and mid-postmenopausal period: a randomized placebo-controlled study.

American journal of therapeutics·2001
Same author

Adequacy of a single stone risk analysis in the medical evaluation of urolithiasis.

The Journal of urology·2001
Same author

Pharmacokinetic and pharmacodynamic comparison of two calcium supplements in postmenopausal women.

Journal of clinical pharmacology·2000
Same journal

From loci to cells: mapping variant function in bone and joint diseases.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

The Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the fourth decade (Part 2).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Is Zoledronic acid cost-saving in daily practice?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

MULTIDIMENSIONAL SPATIAL MAPPING OF EXTRACELLULAR MATRIX: CARTILAGINOUS-OSSEOUS COMPOSITE FORMATION, TENDON INTEGRATION AND VASCULARIZATION DURING SKELETAL GROWTH AND REPAIR.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
See all related articles

Patients with absorptive and fasting hypercalciuria show significantly lower bone density, particularly in the lumbar spine. Environmental factors like sodium intake may contribute to bone loss in absorptive hypercalciuria.

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Hypercalciuria, a condition characterized by elevated calcium levels in urine, is a known risk factor for kidney stone formation.
  • The relationship between hypercalciuria and bone density, particularly in different subtypes of hypercalciuria, requires further investigation.

Purpose of the Study:

  • To compare bone mineral density (BMD) at the lumbar spine and radial shaft in patients with absorptive hypercalciuria, fasting hypercalciuria, and nonhypercalciuric stone formers.
  • To investigate the association between urinary chemistry, body mass index, and bone density in patients with absorptive hypercalciuria.

Main Methods:

  • Dual-energy x-ray absorptiometry (DXA) and single-photon absorptiometry were employed to measure bone density.
  • Sixty-two patients with absorptive hypercalciuria, 27 with fasting hypercalciuria, and 31 controls were included in the study.
Keywords:
NASA Discipline Regulatory PhysiologyNon-NASA Center

Related Experiment Videos

  • Urinary chemistry, including 24-hour excretion of calcium, uric acid, sodium, and sulfate, along with urinary pH, was analyzed.

    • Main Results:

    • Lumbar spine bone density was significantly lower in both absorptive (-10%) and fasting hypercalciuria (-12%) groups compared to controls.
    • A higher percentage of patients with absorptive (74%) and fasting hypercalciuria (92%) exhibited below-normal bone density values.
    • Radial bone density did not differ significantly across the groups, while absorptive hypercalciuria patients with lower bone density showed increased urinary calcium and uric acid excretion and higher BMI.

    Conclusions:

    • Fasting and absorptive hypercalciuria are associated with osteopenia, predominantly affecting trabecular bone in the lumbar spine.
    • Environmental factors, including high sodium and animal protein intake, may play a role in the pathogenesis of bone loss in absorptive hypercalciuria.
    • Urinary chemistry and body mass index are potential contributing factors to reduced bone density in hypercalciuric patients.