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Ciprofloxacin-induced acute interstitial nephritis.

J R Bailey¹, S A Trott, J T Philbrick

¹Department of Medicine, University of Virginia Medical Center, Charlottesville 22908.

American Journal of Nephrology

|January 1, 1992

Summary

Acute interstitial nephritis is a rare complication of fluoroquinolone antibiotics. This case report highlights a patient who developed this kidney injury shortly after starting ciprofloxacin.

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Area of Science:

Nephrology
Pharmacology
Internal Medicine

Background:

Acute kidney injury (AKI) is a significant clinical concern with diverse etiologies.
Medication-induced nephrotoxicity is a well-documented cause of AKI.
Fluoroquinolones are a class of antibiotics with a generally favorable safety profile, but rare adverse effects are increasingly recognized.

Observation:

A case of acute interstitial nephritis (AIN) is presented.
The patient developed AIN within days of initiating ciprofloxacin therapy.
Renal biopsy confirmed the diagnosis of AIN.

Findings:

This report details a rare instance of AIN linked to ciprofloxacin.
Literature review indicates common clinical presentations for this fluoroquinolone-associated nephrotoxicity.
The adverse effect appears to be idiosyncratic and uncommon.

Implications:

Clinicians must maintain awareness of potential AIN from ciprofloxacin.
Early recognition and discontinuation of the offending agent are crucial for managing fluoroquinolone-induced AIN.
Further pharmacovigilance may be warranted for newer fluoroquinolones.

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