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Metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 in rat liver
1Laboratory of Biochemistry, Korea Ginseng and Tobacco Research Institute, Taejon.
Biochemistry International
|November 1, 1992
Abstract:
The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared to be specifically increased by 3-methylcholanthrene- and phenobarbital-inducible P-450, respectively. This suggests that monohydroxylated testosterones are further metabolized by the P-450 system and that the reactions are isozyme specific. This can contribute at least in part to the diversity of steroid metabolism by P-450.