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Related Experiment Videos

Hypertension associated with diffuse small artery calcification: a case report.

E M Hodson1, V F Antico, P O'Neill

  • 1Department of Paediatrics, Westmead Hospital, Sydney, New South Wales, Australia.

Pediatric Nephrology (Berlin, Germany)
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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A young girl with triple X syndrome presented with kidney calcifications and hypertension. Further investigation revealed arterial calcification, but the cause remains unknown.

Area of Science:

  • Pediatric Nephrology
  • Genetics
  • Cardiovascular Pathology

Background:

  • Triple X syndrome (47,XXX) is a chromosomal condition in females.
  • Urinary tract infections (UTIs) can sometimes be associated with renal abnormalities.
  • Hypertension in children requires thorough investigation for underlying causes.

Observation:

  • A 4.5-year-old girl with triple X syndrome developed hypertension and left ventricular hypertrophy.
  • Renal ultrasound revealed echogenic foci in both kidneys, later confirmed as calcifications by CT scan in kidneys, spleen, and pancreas.
  • Biopsy showed calcification within the elastic laminae of superficial temporal and renal arcuate arteries.

Findings:

  • The patient exhibited hypercalciuria but otherwise normal biochemical and hormonal profiles.

Related Experiment Videos

  • Histological findings of arterial calcification were noted, primarily affecting the elastic laminae.
  • No evidence of pseudoxanthoma elasticum or idiopathic arterial calcification of infancy was found.

    • Implications:

    • This case highlights a rare presentation of arterial and renal calcification in a child with triple X syndrome.
    • The etiology and long-term prognosis of this condition are currently unknown.
    • Further research is needed to understand the link between triple X syndrome and vascular calcification.