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Related Experiment Videos

Nucleotide sequence of a complementary DNA for human ST2.

S Tominaga1, T Yokota, K Yanagisawa

  • 1Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.

Biochimica Et Biophysica Acta
|December 29, 1992
PubMed
Summary
This summary is machine-generated.

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Researchers identified human ST2 cDNA, a gene similar to mouse ST2, in activated human T cells. This discovery opens avenues for exploring the physiological role of ST2 in human immune responses.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • ST2 is a gene induced by growth factors, primarily observed in growth-stimulated mouse cells.
  • Human ST2 cDNA shares significant sequence similarity with its murine counterpart.
  • ST2 is structurally related to the extracellular domains of Interleukin-1 Receptors.

Purpose of the Study:

  • To isolate and characterize human ST2 cDNA from activated human helper T cells.
  • To investigate the sequence homology between human and murine ST2.
  • To explore the potential physiological role of ST2 in human lymphocytes.

Main Methods:

  • Isolation of human ST2 cDNA from a T cell line library.
  • Sequence analysis to determine homology with murine ST2.

Related Experiment Videos

  • Comparison of human ST2 protein sequence with Interleukin-1 Receptors.

    • Main Results:

    • Human ST2 cDNA was successfully isolated from an activated human helper T cell line.
    • Human ST2 exhibits 67.6% amino acid identity to murine ST2 over a 327 amino acid overlap.
    • The encoded protein shows remarkable sequence similarity to the extracellular portions of human Interleukin-1 Receptors (types 1 and 2).

    Conclusions:

    • The identification of human ST2 provides a basis for further research into its function.
    • The structural similarity to IL-1 receptors suggests a potential role in cytokine signaling pathways.
    • Investigating ST2 expression in human lymphocytes is crucial for understanding its physiological significance.