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Dopamine transporter imaging with novel, selective cocaine analogs
U Scheffel1, R F Dannals, D F Wong
1Division of Nuclear Medicine and Radiation Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Neuroreport
|November 1, 1992
Abstract:
RTI-121 and RTI-122 are 3 beta-substituted phenyltropane analogs of cocaine that have high, selective binding affinity for dopamine transporters. [123I]RTI-121 and [123I]RTI-122 bind to dopamine transporters in vivo after intravenous administration and permit imaging of the transporters.