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Dobutamine-induced fever.

S R Robison-Strane1, J S Bubik

  • 1St Luke's Medical Center, Milwaukee, WI 53215.

The Annals of Pharmacotherapy
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Fever can be a side effect of dobutamine, a medication used for heart failure. This case highlights the importance of considering dobutamine as a cause of fever in patients, especially when other causes are ruled out.

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Area of Science:

  • Cardiology
  • Clinical Pharmacology

Background:

  • Dobutamine is a common inotropic agent used in managing congestive heart failure.
  • Fever is a potential adverse drug reaction that requires careful evaluation.

Observation:

  • A 71-year-old female patient with congestive heart failure developed unexplained fever during two separate hospitalizations.
  • The fever resolved upon discontinuation of dobutamine and recurred upon its re-administration, suggesting a causal link.

Findings:

  • Differential diagnosis included sepsis relapse and other drug fevers (vancomycin, metoclopramide), which were less likely.
  • Rechallenge with dobutamine confirmed a strong temporal association with fever, with no other confounding factors present.

Implications:

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  • Dobutamine should be considered in the differential diagnosis of fever in patients receiving this medication.
  • Clinicians should be vigilant for adverse drug reactions, including fever, associated with dobutamine therapy.
  • This case underscores the importance of medication review and rechallenge strategies in diagnosing drug-induced fever.