Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Muscle structural modifications in hypoxia.

H Hoppeler1, D Desplanches

  • 1Department of Anatomy, University of Bern, Switzerland.

International Journal of Sports Medicine
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capillary growth, ultrastructure remodelling and exercise training in skeletal muscle of essential hypertensive patients.

Acta physiologica (Oxford, England)·2015
Same author

Endogenous α-calcitonin-gene-related peptide promotes exercise-induced, physiological heart hypertrophy in mice.

Acta physiologica (Oxford, England)·2014
Same author

No change in myonuclear number during muscle unloading and reloading.

Journal of applied physiology (Bethesda, Md. : 1985)·2012
Same author

Effects of eccentric cycle ergometry in alpine skiers.

International journal of sports medicine·2010
Same author

Training in hypoxia and its effects on skeletal muscle tissue.

Scandinavian journal of medicine & science in sports·2008
Same author

Mechanotransduction in striated muscle via focal adhesion kinase.

Biochemical Society transactions·2007
Same journal

Improving assessment of post-exercise hypotension as a predictor of training efficacy.

International journal of sports medicine·2026
Same journal

Neuromuscular electrical stimulation after anterior cruciate ligament reconstruction.

International journal of sports medicine·2026
Same journal

Exercise Intensity Effects on Irisin in Master Athletes and Links With Maximal Oxygen Uptake and Body Fat.

International journal of sports medicine·2026
Same journal

Evolution of the Australian Institute of Sport Supplement Program over the last 25 years.

International journal of sports medicine·2026
Same journal

Preseason Passive Torque Asymmetries in Soccer Players with Hamstring Strain Injury.

International journal of sports medicine·2026
Same journal

Musculoskeletal Burden in German Equestrians: Hip-Specific Symptoms and Risk Factors.

International journal of sports medicine·2026
See all related articles

Prolonged severe hypoxia reduces muscle mass and oxidative capacity. However, intermittent hypoxia during endurance training enhances muscle adaptations, highlighting differing responses to hypoxic stimuli.

Area of Science:

  • Exercise Physiology
  • Human Performance
  • Skeletal Muscle Biology

Background:

  • Prolonged severe hypoxia, like during high-altitude ascents, significantly impacts human physiology.
  • Previous research indicates reductions in body mass, muscle fiber size, and oxidative enzyme activity under such conditions.

Purpose of the Study:

  • To investigate the contrasting effects of prolonged severe hypoxia versus intermittent hypoxic training on human skeletal muscle.
  • To explore the underlying adaptational mechanisms and protein metabolism control in response to different hypoxic exposures.

Main Methods:

  • Analysis of human performance capacity, muscle structure, and function following prolonged severe hypoxia (simulated Mt. Everest ascents).
  • Examination of muscle tissue adaptations (fiber size, capillarity, oxidative capacity) in response to intermittent hypoxic endurance training.

Related Experiment Videos

Main Results:

  • Prolonged hypoxia led to reduced muscle mass, fiber size, and mitochondrial oxidative capacity.
  • Intermittent hypoxic training enhanced muscle fiber size, capillarity, myoglobin concentration, and oxidative capacity.

Conclusions:

  • The type and duration of hypoxic exposure critically determine the adaptive response in skeletal muscle.
  • Findings suggest distinct regulatory pathways for protein metabolism under different hypoxic conditions, warranting further investigation.