Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reflex control of the circulation during exercise.

L B Rowell1

  • 1Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195.

International Journal of Sports Medicine
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentaries.

Canadian Medical Association journal·2010
Same author

Commentaries.

Canadian Medical Association journal·2010
Same author

Commentaries.

Canadian Medical Association journal·2010
Same author

Muscle chemoreflex alters carotid sinus baroreflex response in humans.

Journal of applied physiology (Bethesda, Md. : 1985)·1997
Same author

Neural control of muscle blood flow: importance during dynamic exercise.

Clinical and experimental pharmacology & physiology·1997
Same author

Carotid baroreflex control of blood pressure and heart rate in men during dynamic exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·1994

Central command and the arterial baroreflex explain increased sympathetic nerve activity (SNA) during exercise. This new hypothesis suggests central command resets the baroreflex to elevate blood pressure, influencing cardiovascular responses.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Autonomic Nervous System

Background:

  • Current theories inadequately explain sympathetic nerve activity (SNA) increases during mild exercise.
  • Central command's role in modulating effector activity is understood, but its direct impact on SNA is unclear.
  • Muscle chemo- and mechanoreflexes are not typically active in mild to moderate dynamic exercise.

Purpose of the Study:

  • To propose a new hypothesis explaining the rise in SNA during exercise.
  • To investigate the role of the arterial baroreflex in exercise-induced circulatory control.
  • To reconcile the effects of central command with observed changes in SNA and blood pressure.

Main Methods:

  • The study proposes a new hypothesis based on existing physiological principles.

Related Experiment Videos

  • It reviews the known functions of central command, arterial baroreflexes, and SNA during exercise.
  • Theoretical analysis of the interplay between cardiac output, blood pressure, and baroreflex resetting.

    • Main Results:

    • The arterial baroreflex is maintained during exercise and reset to a higher blood pressure (BP).
    • A new hypothesis posits central command resets the baroreflex to a higher BP and withdraws vagal activity.
    • This mechanism aims to rapidly increase heart rate, cardiac output, and BP at exercise onset.

    Conclusions:

    • Central command may primarily function by resetting the arterial baroreflex to a higher BP set-point.
    • Rapid increases in cardiac output are crucial to meet the new BP target and prevent baroreflex-mediated corrections.
    • This hypothesis offers a more comprehensive explanation for SNA modulation during dynamic exercise.