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Related Experiment Videos

Long term effects of high altitude on brain function.

T F Hornbein1

  • 1University of Washington, Seattle.

International Journal of Sports Medicine
|October 1, 1992
PubMed
Summary

Prolonged exposure to low oxygen levels (hypoxia) can cause mild brain function impairment, affecting memory and concentration. Some individuals, particularly those with a high ventilatory response to hypoxia, may be more susceptible to these neurobehavioral deficits.

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Area of Science:

  • Neurology
  • Environmental Physiology
  • Pulmonary Medicine

Background:

  • Severe hypoxia (lack of oxygen) causes rapid brain injury and unconsciousness.
  • Milder, prolonged hypoxia from high altitudes or chronic lung disease may also affect brain function.
  • The long-term neurobehavioral effects of sustained, sub-conscious hypoxia are not fully understood.

Purpose of the Study:

  • To investigate potential neurobehavioral impairments from prolonged exposure to mild hypoxia.
  • To compare cognitive and motor function in individuals before and after hypoxic exposure.

Main Methods:

  • Review of studies comparing neurobehavioral function in mountaineers before and after high-altitude expeditions.
  • Analysis of studies assessing individuals with chronic pulmonary disease before and after long-term oxygen therapy.

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Main Results:

  • Many studies reported mild neurobehavioral deficits after prolonged hypoxia.
  • Impairments included deficits in memory, aphasia, concentration, and fine motor skills (finger tapping speed).
  • One study noted persistent deficits a year after hypoxic exposure.

Conclusions:

  • Prolonged mild hypoxia may lead to subtle, persistent neurobehavioral impairments.
  • Individuals with a high ventilatory response to hypoxia (HVR) might be at increased risk.
  • Further research is needed to understand susceptibility and long-term effects.