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Synthesis of specific peptide substrates for HIV-1 proteinase
1Department of Physical Chemistry, Roche Products Limited, Welwyn Garden City, Hertfordshire, England.
International Journal of Peptide and Protein Research
|November 1, 1992
Abstract:
Two small peptide substrates for HIV-1 proteinase were synthesised. The sequences chosen were basically from that of the gag-pol protein, which is the natural substrate for the proteinase. To protect these peptides from the attack of exopeptidases, the N- and C-termini were suitably protected, which also makes these substrates specific to HIV-proteinase and eliminates the requirement for highly purified enzyme.