Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgA associated glomerulonephritis.

U N Bhuyan1, S C Dash, R N Srivastava

  • 1Department of Pathology, All-India Institute of Medical Sciences, New Delhi.

The Journal of the Association of Physicians of India
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatrics, Pediatricians and Child Care : Based on 16th Dr. K. C. Chaudhuri and Dr. Amala Chaudhuri Oration, on 15th October 2023.

Indian journal of pediatrics·2024
Same author

Kidney transplantation: The journey across a century.

Medical journal, Armed Forces India·2023
Same author

Cancer trends and burden among Armed Forces personnel, veterans and their families: Cancer registry data analysis from tertiary care hospital.

Medical journal, Armed Forces India·2023
Same author

To compare the outcomes of pancreaticojejunostomy and pancreaticogastrostomy reconstruction after pancreaticoduodenectomy: A prospective observational study.

Medical journal, Armed Forces India·2023
Same author

Outcome of acetabulum fractures treated with open reduction and internal fixation through Kocher-Langenbeck Approach: A retrospective study.

Journal of clinical orthopaedics and trauma·2021
Same author

Chylous Ascites in Nephrotic Syndrome.

Indian pediatrics·2020
Same journal

Indian Expert Consensus on Allergic Rhinitis in Women: A Modified Delphi Survey.

The Journal of the Association of Physicians of India·2026
Same journal

Systematic Review of Topical Capsaicin 0.075% for the Treatment of Neuropathic Pain: Efficacy, Safety, and Tolerability.

The Journal of the Association of Physicians of India·2026
Same journal

Sodium-Glucose Cotransporter 2 Inhibitors in Kidney Diseases Other Than That Due to Diabetes: Benefits in Composite Renal Outcomes Driven by Immunoglobulin A Nephropathy.

The Journal of the Association of Physicians of India·2026
Same journal

<i>Fasciolopsis buski</i> Diagnosed by Upper Gastrointestinal Endoscopy.

The Journal of the Association of Physicians of India·2026
Same journal

"Academic Overdose" among Healthcare Professionals.

The Journal of the Association of Physicians of India·2026
Same journal

Respiratory Examination for Postgraduate Residents: Unrevealing Expert's Questions and Answers.

The Journal of the Association of Physicians of India·2026
See all related articles

Immunoglobulin A associated glomerulonephritis (IgAGN) is uncommon but severe, presenting with high rates of nephrotic syndrome, hypertension, and azotemia, particularly in adults. This study highlights the disease

Area of Science:

  • Nephrology
  • Immunopathology

Background:

  • Immunoglobulin A associated glomerulonephritis (IgAGN) is a primary glomerular disease.
  • Understanding the clinical and histological spectrum of IgAGN is crucial for patient management.

Purpose of the Study:

  • To investigate the incidence, clinical presentation, and histological features of IgA-associated glomerulonephritis (IgAGN) in a cohort of renal biopsies.
  • To characterize the severity and outcomes of IgAGN in both pediatric and adult populations.

Main Methods:

  • Retrospective analysis of 1146 renal biopsies using immunohistological methods.
  • Evaluation of clinical data including nephrotic syndrome, hypertension, and azotemia.
  • Histopathological assessment focusing on glomerular and tubulointerstitial changes.

Related Experiment Videos

Main Results:

  • IgAGN was identified in 7.24% of patients (83/1146), with a higher prevalence in adults (50) than children (33).
  • Clinical presentation was severe: 24% had nephrotic syndrome poorly responsive to prednisolone, 39% had hypertension, and 34% had azotemia.
  • Adults showed higher rates of hypertension and azotemia compared to children.
  • Histology revealed extensive glomerular crescents, sclerosis, moderate arteriolitis/arteriolosclerosis, and marked tubulointerstitial nephropathy.

Conclusions:

  • IgA-associated glomerulonephritis (IgAGN) presents with a low incidence but marked severity.
  • The disease significantly impacts renal function, necessitating further research into optimal treatment strategies.
  • Distinct clinical and histological patterns observed between pediatric and adult patients warrant tailored management approaches.