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Assessment of impaired left ventricular diastolic function in patients with coronary artery disease, using

N K Prasad1, R Oommen, C S Thomas

  • 1Department of Cardiology, Christian Medical College & Hospital, Vellore.

The Journal of the Association of Physicians of India
|July 1, 1992
PubMed

Insights

Left ventricular diastolic dysfunction is common in coronary artery disease (CAD) patients, impacting cardiac filling rates. Radionuclide angiography reveals abnormal LV filling in most CAD patients, irrespective of systolic function.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Physiology

Background:

  • Coronary artery disease (CAD) can affect left ventricular (LV) function.
  • Diastolic dysfunction is a potential consequence of CAD.
  • Non-invasive assessment of LV diastolic filling is crucial for understanding CAD pathophysiology.

Purpose of the Study:

  • To assess left ventricular (LV) diastolic filling in patients with coronary artery disease (CAD).
  • To determine if LV diastolic filling abnormalities are present at rest in CAD patients.
  • To investigate the relationship between LV diastolic filling and systolic function or prior myocardial infarction in CAD.

Main Methods:

  • Utilized radionuclide angiography to evaluate LV diastolic filling at rest.
  • Measured peak LV filling rate (PFR) in end diastolic volume per second (EDV/sec).
  • Measured time to peak LV filling rate (TPFR) in milliseconds (msec).

Main Results:

  • CAD patients exhibited subnormal PFR (1.95 +/- 0.51 EDV/sec) compared to healthy subjects (3.11 +/- 0.36 EDV/sec).
  • CAD patients showed a prolonged TPFR (171.1 +/- 79 msec) versus normal (106.6 +/- 25 msec).
  • Abnormal LV filling was prevalent in 88% of CAD patients, 85% with normal ejection fraction, and 83% without Q waves.

Conclusions:

  • LV diastolic filling is frequently abnormal in CAD patients at rest.
  • Diastolic dysfunction occurs in a high percentage of CAD patients, independent of LV systolic function.
  • Radionuclide angiography is effective for non-invasive detection of diastolic abnormalities in CAD.

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