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Related Experiment Videos

Enalapril in hypertension.

N P Misra1, Y Verma, J Y Shah

  • 1Department of Medicine, Gandhi Medical College & Associated Hospitals, Bhopal, India.

The Journal of the Association of Physicians of India
|July 1, 1992
PubMed
Summary
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Enalapril effectively controls mild to moderate essential hypertension. This angiotensin-converting enzyme inhibitor showed positive results, with many patients achieving normal diastolic blood pressure, sometimes with added diuretics.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Essential hypertension remains a significant global health concern.
  • Long-acting converting enzyme inhibitors offer a potential therapeutic avenue.

Purpose of the Study:

  • To evaluate the efficacy of enalapril in treating essential hypertension.
  • To assess the need for diuretic co-administration in non-responsive cases.

Main Methods:

  • A six-week treatment study involving 30 patients with essential hypertension (25 mild/moderate, 5 severe).
  • Patients received enalapril, with diuretics added for those not responding adequately.

Main Results:

  • Twenty-one of 25 mild/moderate hypertension patients achieved controlled diastolic blood pressure.

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  • Fifteen patients responded to enalapril alone; six required additional diuretics.
  • Limited efficacy was observed in severe hypertension cases, even with diuretics.

    • Conclusions:

    • Enalapril is an effective antihypertensive medication for mild to moderate essential hypertension.
    • Diuretics may be beneficial as an adjunct therapy in select cases.