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Related Experiment Videos

Subcutaneous insulin pulse therapy.

V Seshiah1, S Venkatraman, A Sundaram

  • 1Department of Diabetology, Madras Medical College.

The Journal of the Association of Physicians of India
|July 1, 1992
PubMed
Summary
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Subcutaneous Insulin Pulse Therapy (SIPT) significantly improved glycemic control in patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM). This therapy reduced fasting plasma glucose levels and decreased overall insulin requirements post-treatment.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pharmacology

Background:

  • Non-Insulin Dependent Diabetes Mellitus (NIDDM) management often requires optimized insulin regimens.
  • Preoperative glycemic control is crucial for patients undergoing elective surgery.

Purpose of the Study:

  • To evaluate the efficacy of Subcutaneous Insulin Pulse Therapy (SIPT) in improving glycemic control in NIDDM patients.
  • To assess changes in insulin requirements during and after SIPT.

Main Methods:

  • Fifteen NIDDM patients underwent a 48-72 hour SIPT regimen.
  • Fasting plasma glucose (FPG) and daily insulin doses were monitored before, during, and after SIPT.

Main Results:

  • SIPT significantly reduced mean FPG from 321.28 mgm% to 123.2 mgm% (P < .05).

Related Experiment Videos

  • Post-SIPT conventional therapy required significantly less insulin (71 units/day) compared to the SIPT period (96.42 units/day).

    • Conclusions:

    • Subcutaneous Insulin Pulse Therapy is an effective method for improving glycemic control in NIDDM patients.
    • SIPT can lead to a sustained reduction in insulin dosage requirements.