Peripheral and central nervous system anomalies in HIV-1 infection: an electrophysiological study

This study explored the neurophysiological changes in 87 HIV1+ (20 AIDS, 24 ARC, 24 LAS and 19 AC) patients showing no clinical evidence of neurological impairment. Tracing somatosensory responses by recording SEPs from upper and lower limbs, we found a slowing of both peripheral and central nerve conduction. Peripheral alterations occurred in virtually all patients of the AIDS group. Central anomalies, confined largely to the lower spinal cord, manifested themselves only during the later stages of the disease (ARC and AIDS) and then only in about half of our sample. More marked neurotropic varieties of HIV1 may account for these differences. We feel that SEP studies can serve to reveal pre-clinical NS involvement in HIV1+ subjects and should be included among research strategies aimed at tracing the evolution of AIDS.