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Updated: Jul 15, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

[A case of granulomatous hypophysitis].

R Tanaka¹, T Kameya, K Kasai

¹Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa.

No Shinkei Geka. Neurological Surgery

|December 1, 1992

Summary

A rare case of granulomatous hypophysitis, a pituitary gland inflammation, was diagnosed in a young woman with amenorrhea and lactation. Despite extensive testing, the exact cause remained undetermined, suggesting potential autoimmune origins.

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Area of Science:

Endocrinology
Neuropathology
Immunology

Background:

Pituitary adenomas are common tumors, but inflammatory conditions of the pituitary gland can mimic their presentation.
Granulomatous hypophysitis is a rare inflammatory disorder of the pituitary gland with diverse potential causes.

Observation:

A 25-year-old woman presented with amenorrhea and lactation, and imaging revealed a sella turcica tumor.
Endocrinological tests showed elevated prolactin levels (69.1 ng/ml) with normal basal pituitary hormone levels.
Neurological and funduscopic examinations were unremarkable.

Findings:

Histopathological examination of the resected tumor revealed pituitary destruction with lymphocytes, multinucleated giant cells, calcium deposition, and epithelioid cells, consistent with granulomatous hypophysitis.
Standard etiological investigations for granulomatous hypophysitis (syphilis, tuberculosis, sarcoidosis, fungal infections, Rathke's cleft cyst rupture) were negative.
Immunological investigations and autoantibody studies yielded no positive results, ruling out common autoimmune markers.

Implications:

This case highlights the diagnostic challenges in granulomatous hypophysitis, particularly when typical causes are absent.
The findings suggest a possible autoimmune etiology for granulomatous hypophysitis, even in the absence of serological evidence.
Further research into the pathogenesis of idiopathic granulomatous hypophysitis is warranted.