Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Painful neuropathy: altered central processing maintained dynamically by peripheral input.

Richard H Gracely1, Sue A Lynch, Gary J Bennett

  • 1Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 USA.

Pain
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial A<sub>3</sub> Adenosine Receptor as a Mechanism for the Protective Effects of A<sub>3</sub>AR Agonists on Chemotherapy-Induced Neuropathic Pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

Development of a computerized 2D rating scale for continuous and simultaneous evaluation of two dimensions of a sensory stimulus.

Frontiers in psychology·2023
Same author

Cardiac-Gated Neuromodulation Increased Baroreflex Sensitivity and Reduced Pain Sensitivity in Female Fibromyalgia Patients.

Journal of clinical medicine·2022
Same author

Comparison of Analgesic Prescriptions for Dental Pain and Patient Pain Outcomes Before vs After an Opioid Reduction Initiative.

JAMA network open·2022
Same author

Prescribing Time in Nature for Human Health and Well-Being: Study Protocol for Tailored Park Prescriptions.

Frontiers in digital health·2022
Same author

Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.

Arthritis care & research·2021
Same journal

Pain prevalence and intensity in advanced pancreatic cancer: a nationwide cohort study.

Pain·2026
Same journal

Neurobiology of the trigeminal ganglion in comparison to the dorsal root ganglion.

Pain·2026
Same journal

Peripheral kappa opioid receptors modulate cold hypersensitivity in a mouse model of chemotherapy-induced neuropathy.

Pain·2026
Same journal

Efficacy and effectiveness of melatonin for the management of musculoskeletal pain: a systematic review and meta-analysis of placebo and active controlled trials.

Pain·2026
Same journal

Predictive socio-cultural factors of pain intensity, disability, and quality of life in patients with nonspecific musculoskeletal pain: a prospective cohort study.

Pain·2026
Same journal

Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans.

Pain·2026
See all related articles

Local anesthetic blocks temporarily relieved pain and allodynia in reflex sympathetic dystrophy (RSD) patients by interrupting peripheral nerve input. This suggests a model where peripheral input drives central sensitization in neuropathic pain.

Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Background:

  • Reflex sympathetic dystrophy (RSD) is a complex pain condition characterized by allodynia and spontaneous pain.
  • The underlying mechanisms of RSD, including sympathetically maintained pain (SMP) and sympathetically independent pain (SIP), are not fully understood.

Observation:

  • Sensory assessments were conducted before and during diagnostic tourniquet-cuff and local anesthetic blocks in four patients with RSD.
  • Patients reported mechano-allodynia (pain from light touch) and allodynia to electrical stimuli, suggesting A beta low-threshold mechanoreceptor afferent involvement.
  • Local anesthetic blocks of affected areas abolished mechano-allodynia, cold allodynia, spontaneous pain, and motor symptoms in some patients, with temporary relief.

Findings:

  • Local anesthetic blocks reversibly abolished allodynia and spontaneous pain, indicating a crucial role for peripheral input in maintaining these symptoms.

Related Experiment Videos

  • Differential nerve blocks demonstrated that A beta fibers mediate mechano-allodynia, while thermal sensation remained intact.
  • The findings support a model where peripheral nociceptive input dynamically maintains altered central processing, leading to various sensory and motor abnormalities in neuropathic pain.

    • Implications:

    • Blocking peripheral input can temporarily normalize central processing, offering a potential therapeutic strategy for neuropathic pain conditions like RSD.
    • The proposed model integrates both sympathetically maintained and independent pain, suggesting a shared final common pathway.
    • Further research into peripheral nerve modulation could lead to novel treatments for chronic pain disorders.