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Related Experiment Videos

Oral mesna: a review.

M P Goren1

  • 1Department of Pathology and Laboratory Medicine, St Jude Children's Research Hospital, University of Tennessee, Memphis 38101-0318.

Seminars in Oncology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Oral mesna offers a convenient way to administer ifosfamide therapy at home. This method provides steadier, longer-lasting drug levels and similar safety regarding hematuria compared to IV delivery.

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Similar bioavailability of single-dose oral and intravenous mesna in the blood and urine of healthy human subjects.

Clinical cancer research : an official journal of the American Association for Cancer Research·1998
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Reduction of dimesna to mesna by the isolated perfused rat liver.

Cancer research·1998
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Pharmacokinetics of an intravenous-oral versus intravenous-mesna regimen in lung cancer patients receiving ifosfamide.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1998
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Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.

Cancer chemotherapy and pharmacology·1998
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Combined intravenous and oral mesna in outpatients treated with ifosfamide.

Cancer chemotherapy and pharmacology·1997
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Oral administration of mesna with ifosfamide.

Seminars in oncology·1996

Area of Science:

  • Oncology
  • Pharmacology
  • Urology

Background:

  • Ifosfamide is a chemotherapy agent requiring uroprotection.
  • Mesna is a uroprotective agent used with ifosfamide.
  • Current administration of mesna is primarily intravenous.

Purpose of the Study:

  • To review the oral administration of mesna for ifosfamide therapy.
  • To compare oral versus intravenous mesna delivery.
  • To assess the safety and efficacy of oral mesna.

Main Methods:

  • Review of pharmacology and pharmacokinetics of oral mesna.
  • Analysis of clinical data on efficacy and safety.
  • Examination of reported administration schedules.

Main Results:

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  • Oral mesna provides steadier and more prolonged blood and urinary concentrations than intravenous mesna.
  • The incidence of hematuria is comparable between oral and intravenous mesna therapy.
  • Oral administration facilitates outpatient ifosfamide treatment.

Conclusions:

  • Oral mesna is a viable and effective alternative to intravenous administration.
  • Oral mesna enhances patient convenience and supports outpatient chemotherapy protocols.
  • Further research into optimized oral mesna dosing schedules is warranted.