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Skeletal development and bone functional adaptation.

D R Carter1, T E Orr

  • 1Mechanical Engineering Department, Stanford University, California.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Mechanical loading history guides skeletal development and adult bone remodeling. Stress-regulated mathematical rules explain bone

Area of Science:

  • Biomechanical Engineering
  • Skeletal Biology
  • Computational Modeling

Background:

  • Bone development and remodeling are influenced by mechanical forces.
  • Previous computer models have explored endochondral ossification and bone adaptation.

Purpose of the Study:

  • To review computer models of bone development and remodeling.
  • To explore the role of mechanical loading in skeletogenesis and adult bone adaptation.

Main Methods:

  • Review of existing computer models for bone modeling and remodeling.
  • Analysis of stress-related mathematical algorithms and their application.

Main Results:

  • Simple, stress-related mathematical algorithms can emulate normal skeletal development.

Related Experiment Videos

  • These rules successfully describe adult bone adaptation to altered tissue stresses.

    • Conclusions:

    • Mechanical loading history is crucial for both skeletal development and adult bone remodeling.
    • The same mechanical construction rules may govern development and adult adaptation.