Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular immunity in paracoccidioidomycosis.

Z N Oliveira1, R C Leão, H Goto

  • 1Department of Dermatology, University of São Paulo, Medical School, Brasil.

Allergologia Et Immunopathologia
|July 1, 1992
PubMed
Summary

This study investigated paracoccidioidomycosis in 62 Brazilian patients, analyzing active and cured disease forms and immune responses. Immunological assessments revealed varied results correlating with disease activity and clinical presentation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased expression of in situ CD123 and reduced Toll-like receptor 7/9 signalling pathway suggest impaired activation of plasmacytoid dendritic cells in recurrent erythema multiforme.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Persistence of IgG4 as a potential serological marker of disease activity in patients with epidermolysis bullosa acquisita treated with rituximab.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Increased expression of in situ IL-31RA and circulating CXCL8 and CCL2 in pemphigus herpetiformis suggests participation of the IL-31 family in the pathogenesis of the disease.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Exploring the in situ expression of vascular endothelial growth factor and endoglin in pemphigus foliaceus variants and pemphigus vulgaris.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

Characterization of the humoral and in situ autoantibody profile of scalp involvement in pemphigus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2015

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Paracoccidioidomycosis is a significant mycosis endemic to Latin America.
  • Understanding the immunological profile is crucial for diagnosing and managing paracoccidioidomycosis.

Purpose of the Study:

  • To evaluate the clinical forms and immunological responses in patients with active and cured paracoccidioidomycosis.
  • To correlate paracoccidioidin skin test reactivity with clinical presentation and immune status.

Main Methods:

  • Conducted a 10-year study (1978-1988) on 62 Brazilian patients with paracoccidioidomycosis.
  • Classified patients into active (46) and cured (16) disease groups, detailing clinical forms (acute, chronic unifocal, chronic multifocal).
  • Performed in vivo (skin tests, DNCB sensitization) and in vitro (lymphocyte counts, migration inhibition, chemotaxis, phagocytosis) immunological assessments.

Related Experiment Videos

Main Results:

  • In active disease, 10 patients had acute, 12 chronic unifocal, and 24 chronic multifocal forms.
  • Paracoccidioidin reactivity differed between groups: 16/46 negative and 30/46 positive in active disease; 11/16 positive and 5/16 negative in cured disease.
  • Comprehensive immunological tests provided insights into cellular immunity in paracoccidioidomycosis patients.

Conclusions:

  • Clinical forms of paracoccidioidomycosis exhibit distinct immunological profiles.
  • Paracoccidioidin skin test response is a valuable indicator, though not solely definitive, of disease status.
  • Further immunological investigations are warranted to fully elucidate host-pathogen interactions in paracoccidioidomycosis.