Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Type II diabetes: search for primary defects.

R Turner1, A Hattersley, J Cook

  • 1Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, U.K.

Annals of Medicine
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Global Bioequivalence Harmonisation Initiative (GBHI): Report of the sixth international EUFEPS/PQRI conference.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Estimating the Age of Disease-causal HPV Infection Based on the Natural History of CIN2+ Among Females in Canada.

Open forum infectious diseases·2025
Same author

Psychosocial outcomes after varying risk management strategies in women at increased familial breast cancer risk: a mixed methods study of patient and partner outcomes.

Annals of the Royal College of Surgeons of England·2023
Same author

Drug Permeability - Best Practices for Biopharmaceutics Classification System (BCS)-Based Biowaivers: A workshop Summary Report.

Journal of pharmaceutical sciences·2023
Same author

Analysis of rare disruptive germline mutations in 2135 enriched BRCA-negative breast cancers excludes additional high-impact susceptibility genes.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Corrigenda.

The bone & joint journal·2021
Same journal

Integrative profiling of oral fungal communities across <i>Mycobacterium Tuberculosis</i> burden groups in Xpert-positive patients.

Annals of medicine·2026
Same journal

Prevalence and determinants of alcohol use disorder and its association with adherence to antihypertensive therapy among adult hypertensive patients in a hospital setting, Northwest Ethiopia.

Annals of medicine·2026
Same journal

Early detection of severe fetal growth restriction using multimodal deep learning based on ultrasound and prenatal biomarkers.

Annals of medicine·2026
Same journal

Tinnitus, hyperacusis and somatic complaints in a diverse Norwegian clinical population: implications for assessment and rehabilitation.

Annals of medicine·2026
Same journal

Epidemiological analysis of acute poisoning cases based on Poison control center data from 2021 to 2024.

Annals of medicine·2026
Same journal

Pediatric nurses' stress and their knowledge, attitudes, and practices towards first-aid for pediatric trauma: a latent profile analysis.

Annals of medicine·2026
See all related articles

Type 2 diabetes is likely polygenic, not caused by a single gene. Identifying its genetic causes requires population studies and gene sequencing, not traditional linkage analysis.

Area of Science:

  • Endocrinology
  • Genetics
  • Metabolic Diseases

Background:

  • Type 2 diabetes exhibits familial clustering, suggesting a genetic component.
  • Obesity is a key determinant of insulin resistance, a major feature of Type 2 diabetes.
  • Beta cell dysfunction is essential for Type 2 diabetes development.

Purpose of the Study:

  • To evaluate the genetic basis of Type 2 diabetes.
  • To determine the most effective methods for identifying genes contributing to Type 2 diabetes.

Main Methods:

  • Analysis of nuclear families to assess inheritance patterns.
  • Review of current genetic analysis techniques for complex diseases.
  • Consideration of glucokinase mutations causing maturity-onset diabetes of the young.

Related Experiment Videos

Main Results:

  • Type 2 diabetes is unlikely to be caused by a single dominant gene with high penetrance; it is likely polygenic.
  • Obesity, insulin resistance, and beta cell deficiency may be independently inherited factors.
  • Linkage analysis is of uncertain benefit due to genetic heterogeneity.

Conclusions:

  • Identifying genes for Type 2 diabetes requires population association studies, molecular scanning, and candidate gene sequencing.
  • The genetic architecture of Type 2 diabetes is complex, involving multiple genes and environmental interactions.