Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Muscle differentiation.

T Mohun1

  • 1Laboratory of Developmental Biochemistry, National Institute for Medical Research, Mill Hill, London, UK.

Current Opinion in Cell Biology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Vertebrate skeletal muscle arises from two precursor cell populations. Myogenic regulatory genes like MyoD show functional redundancy and interact with Jun for muscle growth and differentiation control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of ex-vivo high-resolution episcopic microscopy with in-vivo four-dimensional high-resolution transvaginal sonography of the first-trimester fetal heart.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2011
Same author

Myogenesis in Xenopus laevis.

Trends in cardiovascular medicine·2011
Same author

Regulation of cardiac muscle differentiation in Xenopus laevis embryos.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.

The Journal of cell biology·2001
Same author

Subdivision of the cardiac Nkx2.5 expression domain into myogenic and nonmyogenic compartments.

Developmental biology·2000
Same author

Localized XId3 mRNA activation in Xenopus embryos by cytoplasmic polyadenylation.

Mechanisms of development·1999

Area of Science:

  • Developmental biology
  • Molecular genetics
  • Muscle biology

Background:

  • Vertebrate skeletal muscle development involves distinct embryonic precursor cells.
  • The myoD family of genes plays a crucial role in muscle formation.
  • Understanding the regulation of muscle precursor cell differentiation is essential.

Purpose of the Study:

  • To investigate the origins and regulation of vertebrate skeletal muscle precursor cells.
  • To explore the functional redundancy and mechanisms of myogenic regulatory genes.
  • To identify key interactions controlling myoblast growth and differentiation.

Main Methods:

  • Analysis of gene expression patterns in different vertebrate embryos.
  • Systematic mutagenesis of myogenic regulatory genes.

Related Experiment Videos

  • Gene knockout experiments in mice.
  • Biochemical assays to study protein interactions.

    • Main Results:

    • Identified two distinct populations of muscle precursor cells in vertebrates.
    • Demonstrated functional redundancy among myoD family members.
    • Discovered a conserved motif in the basic region of myogenic proteins essential for activity.
    • Showed direct interaction between MyoD/myogenin and the transcription factor Jun.

    Conclusions:

    • Vertebrate skeletal muscle development is orchestrated by distinct precursor cell populations.
    • Myogenic regulatory factors exhibit functional redundancy, with conserved motifs critical for activity.
    • The interaction of MyoD/myogenin with Jun provides a mechanism for integrating muscle cell growth and differentiation signals.