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Translocations (17;20) in colorectal adenocarcinomas
E W Fleischman1, L N Konstantinova, A G Perevozchikov
1Laboratory of Cytogenetics, Russian Academy of Medical Sciences, Moscow.
Cancer Genetics and Cytogenetics
|December 1, 1992
Summary
New chromosome translocations involving chromosomes 17 and 20 were found in colorectal tumors. Researchers identified a novel der(20)t(17;20)(q21;p12) translocation, offering new insights into tumor genetics.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Recurrent chromosomal abnormalities are hallmarks of cancer.
- Chromosome 17 and 20 translocations are implicated in various malignancies.
- Understanding these translocations is crucial for diagnosing and treating colorectal cancer.
Purpose of the Study:
- To identify and characterize novel chromosome translocations in colorectal tumors.
- To report the first instance of the der(20)t(17;20)(q21;p12) translocation.
- To compare newly identified translocations with previously reported ones.
Main Methods:
- Karyotyping of 19 colorectal tumor samples.
- Detailed analysis of chromosome structures and breakpoints.
- Comparison with existing cytogenetic data.
Main Results:
- Three out of 19 colorectal tumors exhibited recurrent chromosome translocations (17;20).
- Two tumors shared an identical translocation: der(20)t(17;20)(q21;p12), leading to loss of 17(pter-->q21).
- A third tumor presented a dicentric dic(17;20)(p11;p12) translocation, with a similar dicentric previously reported.
Conclusions:
- The study identifies novel chromosome translocations (17;20) in colorectal cancer.
- The der(20)t(17;20)(q21;p12) translocation is reported for the first time.
- These findings contribute to the understanding of the genetic landscape of colorectal tumors.