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Translocations (17;20) in colorectal adenocarcinomas

E W Fleischman1, L N Konstantinova, A G Perevozchikov

  • 1Laboratory of Cytogenetics, Russian Academy of Medical Sciences, Moscow.

Cancer Genetics and Cytogenetics
|December 1, 1992
PubMed

Insights

New chromosome translocations involving chromosomes 17 and 20 were found in colorectal tumors. Researchers identified a novel der(20)t(17;20)(q21;p12) translocation, offering new insights into tumor genetics.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Recurrent chromosomal abnormalities are hallmarks of cancer.
  • Chromosome 17 and 20 translocations are implicated in various malignancies.
  • Understanding these translocations is crucial for diagnosing and treating colorectal cancer.

Purpose of the Study:

  • To identify and characterize novel chromosome translocations in colorectal tumors.
  • To report the first instance of the der(20)t(17;20)(q21;p12) translocation.
  • To compare newly identified translocations with previously reported ones.

Main Methods:

  • Karyotyping of 19 colorectal tumor samples.
  • Detailed analysis of chromosome structures and breakpoints.
  • Comparison with existing cytogenetic data.

Main Results:

  • Three out of 19 colorectal tumors exhibited recurrent chromosome translocations (17;20).
  • Two tumors shared an identical translocation: der(20)t(17;20)(q21;p12), leading to loss of 17(pter-->q21).
  • A third tumor presented a dicentric dic(17;20)(p11;p12) translocation, with a similar dicentric previously reported.

Conclusions:

  • The study identifies novel chromosome translocations (17;20) in colorectal cancer.
  • The der(20)t(17;20)(q21;p12) translocation is reported for the first time.
  • These findings contribute to the understanding of the genetic landscape of colorectal tumors.

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