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Related Experiment Videos

Pyoderma faciale in a patient with Crohn's disease.

P M McHenry1, M Hudson, L M Smart

  • 1Department of Rheumatology, Aberdeen Royal Infirmary, Foresterhill, UK.

Clinical and Experimental Dermatology
|November 1, 1992
PubMed
Summary

This case study highlights a patient with pyoderma faciale and Crohn's disease. Isotretinoin therapy proved effective for the skin condition, with relapses linked to non-steroidal anti-inflammatory drugs.

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Pyoderma faciale is a rare, severe facial dermatitis.
  • Crohn's disease is a chronic inflammatory bowel disease.
  • The co-occurrence of these conditions presents unique clinical challenges.

Observation:

  • A patient with established Crohn's disease developed pyoderma faciale.
  • Two distinct instances of pyoderma faciale relapse were observed.
  • These relapses temporally correlated with the initiation of non-steroidal anti-inflammatory drug (NSAID) therapy.

Findings:

  • NSAIDs may exacerbate or trigger pyoderma faciale in susceptible individuals, particularly those with inflammatory bowel disease.
  • Isotretinoin treatment demonstrated efficacy in resolving the patient's pyoderma faciale.

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  • The therapeutic course with isotretinoin was well-tolerated by the patient.

    • Implications:

    • This case highlights a potential adverse drug reaction between NSAIDs and pyoderma faciale in Crohn's disease patients.
    • It suggests careful consideration of NSAID use in patients with co-existing pyoderma faciale and Crohn's disease.
    • Isotretinoin represents a viable therapeutic option for managing pyoderma faciale in this complex patient population.