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Updated: Aug 27, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Tools for microwave-assisted parallel syntheses and combinatorial chemistry
Matthias Nüchter1, Bernd Ondruschka
1Institute of Technical Chemistry and Environmental Chemistry, Friedrich Schiller University Jena, Lessingstr 12, D-07743 Jena, Germany. matthias.nuechter@uni-jena.de
Abstract:
A protocol for transferring conventional reactions to the microwave field explores the effectiveness of parallel syntheses and combination approaches. Applicability to the reaction systems combiCHEM, multiPREP, MMR8 and HPR is defined. Model reactions have been performed in laboratory equipment. Emphasis is placed on similar reaction conditions in the individual vessels and the repeatability of results. Outcomes include esterifications and multi-center reactions exhibiting a great potential for combinatorial chemistry.
