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Ifosfamide containing regimen for non-small cell lung cancer
D Behera1, A N Aggarwal, S C Sharma
1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dbehera@glide.net.in
Combination chemotherapy with mitomycin, ifosfamide, and cisplatin shows efficacy in advanced non-small cell lung cancer (NSCLC). Survival improves with more cycles, with minimal side effects and acceptable cost.
Area of Science:
- Oncology
- Medical Chemotherapy
Background:
- Combination chemotherapy is a leading treatment for non-small cell lung cancer (NSCLC).
- Advanced unresectable NSCLC (Stage III B or IV) requires effective therapeutic strategies.
Purpose of the Study:
- To evaluate the efficacy and tolerability of a combination chemotherapy regimen.
- To assess the impact of chemotherapy cycles on survival in advanced NSCLC patients.
Main Methods:
- A total of 206 patients with advanced NSCLC were enrolled.
- Patients received combination chemotherapy with mitomycin, ifosfamide, and cisplatin.
- Treatment continuation and outcomes were monitored.
Main Results:
- Nearly half of patients achieved partial or complete radiological response.
- Overall median survival was 20 weeks, improving with more chemotherapy cycles administered.
- Survival rates at 12 months were 9.8%, with significant correlation to baseline performance status.
Conclusions:
- The mitomycin, ifosfamide, and cisplatin regimen is an effective chemotherapeutic option for advanced NSCLC.
- The regimen is well-tolerated with minimal side effects and a cost of approximately $100 per course.
- Increased chemotherapy cycles correlate with improved survival outcomes in NSCLC patients.
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