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Related Experiment Videos

Tailor-made functional surfaces: potential elastomeric biomaterials I.

Shrojal Desai1, Dhananjay Bodas, K R Patil

  • 1Polymer Chemistry Division, National Chemical Laboratory, Pune 41108, India.

Journal of Biomaterials Science. Polymer Edition
|February 12, 2004
PubMed
Summary
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Researchers modified EPDM films using simultaneous photo-grafting and cold plasma-grafting with functional monomers. This enhanced surface hydrophilicity and biocompatibility, with hydroxyethyl methacrylate and acrylic acid showing superior cell adhesion and proliferation.

Area of Science:

  • Polymer Science
  • Materials Science
  • Biomaterials Engineering

Background:

  • Ethylene Propylene Diene Monomer (EPDM) films are widely used but often require surface modification to improve biocompatibility.
  • Traditional post-plasma grafting can be less efficient than simultaneous methods.
  • Enhancing surface hydrophilicity is crucial for improving cell interactions with polymeric materials.

Purpose of the Study:

  • To investigate simultaneous photo- and cold plasma-grafting techniques for modifying EPDM film surfaces.
  • To evaluate the impact of different functional monomers on surface properties and biocompatibility.
  • To compare simultaneous grafting with conventional post-plasma grafting methods.

Main Methods:

  • Simultaneous photo-grafting (wavelength > or = 290 nm) and cold plasma-grafting of EPDM films.

Related Experiment Videos

  • Grafting of functional monomers: hydroxyethyl methacrylate, acrylic acid, N-vinyl pyrrolidone, and glycidyl methacrylate.
  • Surface characterization using Attenuated Total Reflection Fourier Transform Infrared (ATR-FT-IR) spectroscopy, X-ray Photoelectron Spectroscopy (XPS), and Scanning Electron Microscopy (SEM).
  • Evaluation of hydrophilicity via water contact angle measurements and biocompatibility through in vitro human carcinoma cell adhesion/proliferation tests.

    • Main Results:

    • Chemical modifications on the EPDM surface were confirmed by ATR-FT-IR and XPS, indicating successful monomer grafting.
    • SEM analysis revealed changes in surface morphology post-grafting.
    • Increased hydrophilicity was observed, correlating with improved cell compatibility.
    • All grafted EPDM films demonstrated enhanced cell compatibility compared to unmodified films.
    • Hydroxyethyl methacrylate and acrylic acid exhibited particularly high cell adhesion and proliferation rates.

    Conclusions:

    • Simultaneous photo- and cold plasma-grafting are effective methods for surface modification of EPDM films.
    • The choice of functional monomer significantly influences the degree of surface modification and biocompatibility.
    • EPDM films grafted with hydroxyethyl methacrylate and acrylic acid show promising potential for biomedical applications due to superior cell compatibility.