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Outcome measurement in pharmacological trials: validity of the Routine Assessment of Patient Progress (RAPP)
T S Ehmann1, T Kragelj, G N Smith
1Department of Psychiatry, St Vincent's Hospital, Vancouver, BC, Canada. tomse@telus.net
Journal of Psychopharmacology (Oxford, England)
|February 12, 2004
Summary
The Routine Assessment of Patient Progress (RAPP) scale effectively measures changes in psychiatric inpatients receiving antipsychotic medication. It demonstrates validity as an outcome measure in treatment trials, comparable to other scales.
Area of Science:
- Psychiatry
- Clinical Psychology
- Pharmacology
Background:
- Assessing treatment outcomes with antipsychotic medication is crucial for psychiatric care and research.
- The Routine Assessment of Patient Progress (RAPP) is a validated tool for evaluating psychiatric inpatient symptoms and functioning.
- Further validation is needed to confirm RAPP's sensitivity to change during antipsychotic treatment.
Purpose of the Study:
- To extend validity evidence for the RAPP scale.
- To assess the RAPP's ability to reflect changes in patients treated with antipsychotic medications.
- To replicate previous validity data using a new patient sample.
Main Methods:
- Ninety-seven trials were conducted with 65 psychiatric inpatients receiving specialized treatment.
- The RAPP, Positive and Negative Syndrome Scale (PANSS), and global severity measures were administered at baseline and trial end.
- Factor scores, subscales, and total scores were analyzed for sensitivity to change.
Main Results:
- RAPP scores (factor, clinical, total) showed favorable comparison to other outcome measures in patients who improved or worsened.
- RAPP scores demonstrated significantly less change than PANSS scores in patients rated as unchanged.
- The RAPP scale proved sensitive to treatment-induced changes in psychiatric symptoms and functioning.
Conclusions:
- The RAPP scale is a valid outcome measure for antipsychotic medication treatment trials.
- The findings support the RAPP's utility in assessing patient progress in clinical and research settings.
- The RAPP scale reliably captures meaningful changes in psychiatric inpatients.
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