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Influence of a self-etching primer on compound nerve action potentials
Zafer C Cehreli1, Fugen Tasman, Mehmet Ali Onur
1Department of Pediatric Dentistry, Faculty of Dentistry, Hacettepe University, Sihhiye 06100, Ankara, Turkey. zcehreli@hacettepe.edu.tr
Journal of Biomaterials Applications
|February 12, 2004
Summary
Self-etching primers, like One Up Bond F, rapidly and irreversibly block nerve conductance. This suggests potential clinical effectiveness for dentin desensitization compared to other bonding agents.
Area of Science:
- Biomaterials Science
- Neuroscience
- Dental Materials
Background:
- Dental bonding agents are used for dentin desensitization.
- Evaluating the neurotoxic effects of dental materials is crucial for patient safety.
- Self-etching primers offer a simplified application process in dentistry.
Purpose of the Study:
- To assess the impact of a self-etching primer (One Up Bond F) on nerve function.
- To compare the nerve conductance effects of One Up Bond F with a fifth-generation bonding agent (Prime&Bond NT).
Main Methods:
- Isolated rat sciatic nerves were used to measure compound action potentials (CAP).
- Nerves were exposed to One Up Bond F and Prime&Bond NT in a Tyrode solution.
- CAPs were recorded before and after material application to evaluate nerve conductance.
Main Results:
- One Up Bond F caused irreversible nerve blockade within an average of 7 minutes.
- Prime&Bond NT resulted in a 45.9% reduction in CAP after 15 minutes, with partial recovery observed.
- The self-etching primer demonstrated significantly faster nerve conductance inhibition.
Conclusions:
- One Up Bond F exhibits a potent and rapid inhibitory effect on nerve conductance.
- The findings suggest that self-etching primers may offer superior clinical efficacy for dentin desensitization due to their nerve-blocking properties.