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Human cytomegalovirus and Epstein-Barr virus type 1 in periodontal abscesses

I Saygun1, M Yapar, A Ozdemir

  • 1Department of Periodontology, Gülhane Military Medical Academy, Ankara, Turkey. saygunisil@hotmail.com

Oral Microbiology and Immunology
|February 12, 2004
PubMed
Abstract

Insights

Herpesviruses, including human cytomegalovirus (HCMV) and Epstein-Barr virus type 1 (EBV-1), are frequently detected in periodontal abscesses. Treatment eliminated these viruses, suggesting their role in abscess development.

Area of Science:

  • Oral microbiology
  • Virology
  • Periodontology

Background:

  • Herpesviruses are linked to severe periodontal disease.
  • The role of herpesviruses in periodontal abscesses is unknown.

Purpose of the Study:

  • Determine the presence of human cytomegalovirus (HCMV) and Epstein-Barr virus type 1 (EBV-1) in periodontal abscesses.
  • Assess the impact of treatment on HCMV and EBV-1 occurrence.

Main Methods:

  • Subgingival samples were collected from 18 adults with periodontal abscesses.
  • Samples were taken from abscess sites and healthy control sites.
  • HCMV and EBV-1 were detected using polymerase chain reaction before and after treatment.

Main Results:

  • HCMV was found in 66.7% of abscess sites vs. 5.6% of healthy sites.
  • EBV-1 was found in 72.2% of abscess sites vs. 0% of healthy sites.
  • HCMV and EBV-1 co-infection occurred in 55.6% of abscess sites; treatment cleared both viruses.

Conclusions:

  • HCMV and EBV-1 are common in periodontal abscesses.
  • Herpesvirus infection may compromise host defenses, facilitating bacterial entry and abscess formation.

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