Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oral snuff impairs endothelial function in healthy snuff users.

M Rohani1, S Agewall

  • 1Department of Cardiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.

Journal of Internal Medicine
|February 12, 2004
PubMed
Summary

Oral moist snuff use significantly impairs brachial artery endothelial function, a predictor of cardiovascular disease. This finding suggests that oral snuff, despite perceptions of reduced harm, should be discouraged due to its negative vascular effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of antioxidant activity of novel potential probiotic cocktail in mice model of gut inflammation via oxidative stress-related pathways.

Beneficial microbes·2026
Same author

Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold.

The Journal of laryngology and otology·2023
Same author

Pharmacological treatment of CVD.

European heart journal. Cardiovascular pharmacotherapy·2022
Same author

Future of European Heart Journal Cardiovascular Pharmacotherapy.

European heart journal. Cardiovascular pharmacotherapy·2022
Same author

To treat or not to treat.

European heart journal. Cardiovascular pharmacotherapy·2022
Same author

The potential role of Bifidobacterium spp. as a preventive and therapeutic agent in controlling inflammation via affecting inflammatory signalling pathways.

Letters in applied microbiology·2022

Area of Science:

  • Cardiovascular Science
  • Vascular Biology
  • Toxicology

Background:

  • Endothelial dysfunction is a predictor of cardiovascular morbidity.
  • Oral snuff is sometimes considered a less harmful alternative to cigarette smoking.
  • The acute effects of oral moist snuff on endothelial function are not well-established.

Purpose of the Study:

  • To investigate whether acute use of oral moist snuff induces endothelial dysfunction.
  • To assess the impact of oral moist snuff on flow-mediated dilatation (FMD) of the brachial artery.

Main Methods:

  • A randomized, placebo-controlled, cross-over study was conducted.
  • Twenty healthy middle-aged male snuff users participated.
  • Ultrasound assessed endothelial-dependent flow-mediated dilatation (FMD) before and after snuff or placebo administration.

Related Experiment Videos

Main Results:

  • Oral moist snuff significantly reduced FMD from 3.4% to 2.3% 35 minutes post-administration (P < 0.05).
  • Heart rate and blood pressure also increased significantly after snuff use.
  • No significant changes were observed after placebo administration.

Conclusions:

  • Acute oral moist snuff use significantly impairs brachial artery endothelial function.
  • Endothelial dysfunction is a key factor in cardiovascular disease development.
  • The use of oral snuff should be discouraged due to its adverse vascular effects.