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Updated: Aug 27, 2026

Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes
Published on: September 24, 2013
Molecular determinants of cardiac memory and their regulation
Kornelis W Patberg1, Michael R Rosen
1Department of Pharmacology, Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, 630 West 168 Street, PH 7W-321, New York, NY 10032, USA.
Abstract:
Cardiac memory is characterized by an altered T-wave on electrocardiogram or vectorcardiogram recorded during sinus rhythm, having been induced by a preceding period of abnormal ventricular activation. This phenomenon reflects the dynamic ability of the heart to adapt to new circumstances, in this instance, an altered electrical activation pattern. The result of this adaptation is a changed electrical substrate expressed in cardiac repolarization. The signal transduction mechanisms and ion channel changes that are initiated by altered activation and that contribute to the expression of cardiac memory are the major focus of this review. Studies of non-cognitive memory in central nervous system have provided a paradigm for much of this research.
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