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TIMP-1 alters susceptibility to carcinogenesis

Jin-Sae Rhee1, Robert Diaz, Lidiya Korets

  • 1Medical Scientist Training Program, Cancer Research Institute, University of California, San Francisco, California, USA.

Cancer Research
|February 12, 2004
PubMed
Summary

Tissue inhibitors of metalloproteinases (TIMPs) enhance epithelial carcinogenesis by promoting keratinocyte hyperproliferation and chromosomal aberrations. TIMP-1 contributes to neoplastic progression but does not prevent malignant conversion or metastasis.

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