Soluble interleukin-2 receptors in recurrent miscarriage and the effect of leukocyte immunotherapy

The relationship between soluble interleukin-2 receptors (IL-2R) and pregnancy outcome was investigated in women with a history of miscarriage, some of whom were treated with partner-specific leukocyte immunotherapy. IL-2R were significantly elevated in patients with a poor obstetric history possessing cardiolipin antibodies, and higher levels were also found in recurrent aborters without cardiolipin antibodies who had particularly bad histories. Furthermore, values obtained during early pregnancy were lower in patients who subsequently had successful pregnancies than in those who aborted again. Eight out of 35 patients immunised with their partners' lymphocytes, but none of 16 patients immunised with their own cells, showed a marked decrease in IL-2R levels a month later. It is possible that the minority who respond to immunotherapy with a marked drop in IL-2R may be the same minority who may derive benefit from this treatment.