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Maternal psychotropic medication and neonatal behavior.

J G Auerbach1, S L Hans, J Marcus

  • 1Department of Psychology, Hebrew University of Jerusalem.

Neurotoxicology and Teratology
|November 1, 1992
PubMed
Summary
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Maternal antipsychotic medication during pregnancy may lead to poor neonatal motor function in infants. This can manifest as a withdrawal syndrome, affecting motor skills and maturity.

Area of Science:

  • Perinatal Psychiatry
  • Neonatal Neurology
  • Developmental Psychology

Background:

  • Pregnancy involves significant physiological changes.
  • Psychiatric conditions and medications can impact fetal development.
  • Neonatal behavioral assessment is crucial for understanding infant well-being.

Purpose of the Study:

  • To investigate the effects of maternal antipsychotic and anti-anxiety medication during pregnancy on neonatal behavior.
  • To compare the motor functioning of infants exposed to these medications with controls.

Main Methods:

  • Recruited pregnant women with psychiatric conditions and a non-ill comparison group.
  • Assessed infant behavior at 3 and 14 days using the Brazelton Neonatal Behavioral Assessment Scale.
  • Compared infants of medicated mothers, non-medicated ill mothers, and non-ill mothers.

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Main Results:

  • Infants of mothers on antipsychotic drugs (especially phenothiazines) exhibited consistent poor neonatal motor functioning.
  • Observed issues included tremulousness, hypertonicity, and immature motor development.
  • These findings were distinct from infants of non-ill and non-medicated ill mothers.

Conclusions:

  • Maternal antipsychotic use during pregnancy may result in a neonatal abstinence or withdrawal syndrome.
  • Infants exposed to certain psychiatric medications in utero may show specific patterns of impaired motor development.
  • Further research is warranted to understand the long-term implications and mechanisms of medication-induced neonatal behavioral changes.