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Photocontact dermatitis due to piroxicam: photopatch testing
1Division of Dermatology, Tohoku Kosei-Nenkin Hospital, Sendai.
The Tohoku Journal of Experimental Medicine
|August 1, 1992
Summary
Photocontact dermatitis can occur from piroxicam gel, a nonsteroidal anti-inflammatory drug. This case highlights a link between thiosalicylate sensitivity and piroxicam photosensitivity.
Area of Science:
- Dermatology
- Photodermatology
- Contact Dermatitis
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Piroxicam gel is a topical NSAID formulation.
- Photocontact dermatitis is an immune reaction triggered by a substance and light.
Observation:
- A 62-year-old male presented with itchy, eczematous skin lesions after using piroxicam gel.
- The patient developed symptoms within two days of application.
- Photopatch testing revealed positive reactions to ultraviolet A and piroxicam.
Findings:
- Patch testing showed positive reactions to thimerosal, thiosalicylate, and an in vitro irradiated solution of piroxicam with human serum albumin.
- Tests for mercurial compounds were negative.
- The results suggest a correlation between thiosalicylate sensitivity and piroxicam-induced photosensitivity.
Implications:
- This case underscores the potential for piroxicam gel to cause photocontact dermatitis.
- It highlights a potential cross-reactivity between thiosalicylate, a component of thimerosal, and piroxicam.
- Further investigation into this relationship may inform clinical practice and product safety regarding NSAID formulations.