Related Experiment Videos
Active and passive immunization for tetrodotoxin in mice
1Yamaguchi Prefectural Research Institute of Health, Japan.
This study describes the possibility of active and passive immunization for tetrodotoxin (TTX) poisoning. TTX was conjugated to keyhole limpet hemocyanin and this conjugate was used as an immunogen in rabbits and mice. Mice immunized with the conjugate were protected from a lethal dose of TTX. Passive protection experiments demonstrated that immunoglobulin from rabbit antiserum exhibited a dose-related therapeutic activity in mice after challenge with TTX.
This study describes the possibility of active and passive immunization for tetrodotoxin (TTX) poisoning. TTX was conjugated to keyhole limpet hemocyanin and this conjugate was used as an immunogen in rabbits and mice. Mice immunized with the conjugate were protected from a lethal dose of TTX. Passive protection experiments demonstrated that immunoglobulin from rabbit antiserum exhibited a dose-related therapeutic activity in mice after challenge with TTX.