[Chromosome aberrations in chronic myeloid leukemia]

Chromosome Philadelphia is a cytogenetic marker of chronic myeloid leukemia. It results from a translocation t(9;22) or other, more complex, translocations. Before the onset of blastic crisis, secondary aberrations occur, the most often--trisomy 8, isochromosome 17q and extra Ph chromosome. Their presence has a prognostic significance. Particular aberrations may occur in association with determined haematological and clinical features.