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Related Experiment Videos

Thrombolysis with low dose tissue plasminogen activator.

E Doyle1, J Britto, J Freeman

  • 1Intensive Care Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow.

Archives of Disease in Childhood
|December 1, 1992
PubMed
Summary

Low-dose local infusions of tissue plasminogen activator successfully treated infant vena cava thrombosis when anticoagulants failed. This regional approach effectively dissolves clots linked to catheters with minimal systemic impact.

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Area of Science:

  • Pediatric Thrombosis
  • Vascular Medicine
  • Interventional Cardiology

Background:

  • Vena cava thrombosis in infants is a serious condition often linked to indwelling intravascular catheters.
  • Conventional anticoagulant therapy can be ineffective for managing these clots.
  • Limited treatment options exist for complex cases of infant vena cava thrombosis.

Observation:

  • Two infant cases of vena cava thrombosis were analyzed.
  • Previous anticoagulant treatments were unsuccessful in both cases.
  • A novel low-dose local infusion of tissue plasminogen activator was administered.

Findings:

  • Successful clot lysis was achieved using low-dose (0.01-0.05 mg/kg/hour) regional tissue plasminogen activator infusions.
  • The treatment was particularly effective for clots associated with indwelling intravascular catheters.

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  • Minimal systemic side effects were observed during the regional application.

    • Implications:

    • Low-dose local tissue plasminogen activator infusion represents a viable and effective treatment strategy for infant vena cava thrombosis.
    • This regional approach offers a safer alternative to systemic thrombolysis, minimizing potential complications.
    • Further research into regional thrombolysis for pediatric venous thromboembolism is warranted.