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Related Experiment Videos

[Discrepant results with immunohistochemical detection TDx/ADx?].

M Franke1, S Goenechea, F Heinbach

  • 1Institut für Rechtsmedizin, Universität Bonn.

Beitrage Zur Gerichtlichen Medizin
|January 1, 1992
PubMed
Summary

Immunoassay systems TDx/ADx showed reproducible results, despite initial discrepancies with thin-layer chromatography for drug screenings like amphetamines and cocaine. Further testing confirmed the reliability of these immunoassay methods.

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Area of Science:

  • Clinical Chemistry
  • Forensic Toxicology
  • Analytical Chemistry

Background:

  • Significant discrepancies (20%) were observed between thin-layer chromatography (TLC) and immunoassay (TDx/ADx) drug screening results over a two-year period.
  • These discrepancies involved common drug classes: amphetamines, opiates, benzodiazepines, barbiturates, and cocaine.
  • The high rate of disagreement necessitated a thorough investigation into the reliability of the immunoassay systems.

Purpose of the Study:

  • To evaluate the compatibility and performance of the TDx and ADx immunoassay systems.
  • To determine the detection limits of the TDx and ADx systems.
  • To compare immunoassay results with a validated reference method, thin-layer chromatography.

Main Methods:

  • Conducted 883 urine sample screenings between January 1989 and December 1990.

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  • Utilized both TDx and ADx immunoassay systems for drug detection.
  • Employed thin-layer chromatography as a comparative method.
  • Calculated correlation coefficients to statistically validate the findings.

    • Main Results:

    • Despite initial discrepancies, statistical analysis using correlation coefficients demonstrated that both TDx and ADx systems are reproducible.
    • The study confirmed the reliability of the TDx and ADx immunoassay systems for drug screening.

    Conclusions:

    • The TDx and ADx immunoassay systems provide reproducible results for drug screening.
    • While initial discrepancies were noted, the systems' performance was validated through comparative analysis and statistical correlation.