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Reference limits of plasma fibrinogen.

P Tarallo1, J Henny, R Gueguen

  • 1Département de Biologie Clinique, URA CNRS 597, Vandoeuvre-les-Nancy, France.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|November 1, 1992
PubMed
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Plasma fibrinogen levels increase with age in adults and correlate with weight. Factors like oral contraceptive use, smoking, and alcohol consumption also influence fibrinogen, a key cardiovascular disease predictor.

Area of Science:

  • Cardiovascular Disease Research
  • Clinical Chemistry
  • Biomarker Analysis

Background:

  • Fibrinogen is a significant predictor of cardiovascular diseases.
  • Understanding baseline fibrinogen levels and influencing factors is crucial for risk assessment.

Purpose of the Study:

  • To determine baseline plasma fibrinogen concentrations in a healthy population aged 4-60 years.
  • To investigate the relationship between fibrinogen levels and age, sex, body weight, smoking, alcohol consumption, and oral contraceptive use.

Main Methods:

  • Kinetical measurement of plasma fibrinogen using the Behring Chromotimer and CTS-fibrinogen method.
  • Statistical analysis including Pearson's correlations and linear multiple regression models.
  • Study population comprised 1008 apparently healthy subjects.
Keywords:
Age FactorsAlcohol DrinkingBehaviorBiologyBlood PressureBody WeightCholesterolContraceptionContraceptive Methods--side effectsData AnalysisDemographic FactorsExaminations And DiagnosesFamily PlanningHematologic TestsHematological EffectsHemic SystemLaboratory Examinations And DiagnosesLaboratory ProceduresLipidsMultivariate AnalysisOral Contraceptives--side effectsPhysiologyPopulationPopulation CharacteristicsResearch MethodologySex FactorsSmokingStatistical StudiesStudies

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Main Results:

  • No significant difference in fibrinogen between boys and girls (4-20 years) or correlation with cardiovascular risk factors.
  • In adults, plasma fibrinogen increased with age; no sex difference except 40-50 years.
  • Positive correlation between fibrinogen and ponderal index (body weight).
  • Oral contraceptive use in women (20-30 years) increased fibrinogen by 0.19 g/l.
  • Smoking increased fibrinogen in 30-40 year-old men (0.35 g/l per cigarette/day).
  • Alcohol consumption negatively correlated with fibrinogen (women: -0.008 g/l per g alcohol/day; men: -0.004 g/l per g alcohol/day).

Conclusions:

  • Fibrinogen levels are influenced by age, body weight, oral contraceptive use, smoking, and alcohol consumption in adults.
  • These factors should be considered when assessing cardiovascular disease risk associated with fibrinogen levels.
  • Fibrinogen serves as a valuable biomarker for cardiovascular health across different demographics.