Effect of ethylene glycol on transcription of Neurospora crassa conidial genome

Ethylene glycol (EG) was found not to alter DNA sequences in Neurospora crassa conidia, though it is believed to be mutagenic in nature. Molecular hybridization revealed 20% increase in whole RNA transcripts in EG-treated conidia, which indicates that while untreated conidia increase RNA synthesis by 2.35fold, treated conidia are inhibited and undergo only a 1.2fold increase. Thus there is an inhibition in potential RNA synthesis, though some RNA synthesis goes on in presence of ethylene glycol.