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CD11B lymphocytes in type 1 diabetes mellitus of recent onset
A Bizzarro1, A De Bellis, V Amoresano Paglionico
1Cattedra di Patologia Speciale Medica e Metodologia Clinica 3, Naples, Italy.
Hormone and Metabolic Research. Supplement Series
|January 1, 1992
Abstract:
To evaluate the behaviour of CD8+ cells (suppressor/cytotoxic T lymphocytes) and CD8+Leu15+ cells (CD11B, suppressor T lymphocytes) in type 1 diabetes mellitus, 27 newly diagnosed diabetic patients and 47 normal controls were studied. CD8 cells were significantly increased in 6 patients, decreased in 9 and unchanged in 12. In all diabetic patients was present a lack of CD8+ Leu15+ cells. These results show that in newly diagnosed type 1 diabetes mellitus, suppressor T lymphocytes are reduced independently from the number of CD8 cells.