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Increased platelet activity in diabetic macroangiopathy.

E J Diamantopoulos¹, S A Raptis, S D Moulopoulos

¹Second Department of Internal Medicine-Propaedeutic, Athens University Medical School, Evangelismos Hospital, Greece.

Hormone and Metabolic Research. Supplement Series

|January 1, 1992

Summary

Diabetics show increased platelet activity, particularly those with peripheral occlusive arterial disease (POAD). This heightened platelet release reaction, indicated by elevated beta-thromboglobulin (beta-TG), occurs even in early diabetic angiopathy stages.

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Area of Science:

Endocrinology
Vascular Biology
Hematology

Background:

Diabetic macroangiopathy is a significant complication of diabetes mellitus.
Platelet activation is implicated in the pathogenesis of vascular disease.

Purpose of the Study:

To investigate the relationship between in vivo platelet activity and diabetic macroangiopathy.
To measure plasma beta-thromboglobulin (beta-TG) concentrations in diabetic patients with and without vascular complications.

Main Methods:

Radioimmunoassay was used to measure plasma beta-thromboglobulin (beta-TG) levels.
Study included 55 diabetic patients and 27 healthy controls.
Peripheral occlusive arterial disease (POAD) diagnosis was confirmed by Doppler ultrasound and arteriography.

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Main Results:

Mean plasma beta-TG concentrations were significantly higher in diabetics compared to controls (p < 0.001).
Diabetics with POAD exhibited the highest beta-TG levels (106.50 +/- 52.65 ng/ml).
Elevated beta-TG levels were observed even in diabetics without clinically apparent vascular lesions.

Conclusions:

Diabetics exhibit an increased platelet release reaction and enhanced in vivo platelet activity.
Elevated platelet activity is particularly pronounced in diabetic patients with POAD.
Increased platelet activity may be an early indicator of diabetic angiopathy, preceding clinical manifestation.