Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The quinine connection.

D Greenwood1

  • 1Department of Microbiology, University Hospital, Queen's Medical Center, Nottingham, UK.

The Journal of Antimicrobial Chemotherapy
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

The discovery of aniline dyes, initially accidental, revolutionized antimicrobial research. This led to the development of sulfa drugs, paving the way for modern antibiotics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of the Manchester framework for the evaluation of emergency department pharmacy services.

International journal of clinical pharmacy·2022
Same author

The description and definition of Emergency Department Pharmacist Practitioners in the United Kingdom (the ENDPAPER study).

International journal of clinical pharmacy·2019
Same author

Long-term health effects of chemical warfare agents on children following a single heavy exposure.

Human & experimental toxicology·2017
Same author

Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Transformation of the forage legume Trifolium repens L. using binary Agrobacterium vectors.

Plant molecular biology·2013
Same journal

Favipiravir tissue distribution and inhibitory quotients in preclinical models: towards a pipeline for evidence-based antiviral repurposing.

The Journal of antimicrobial chemotherapy·2026
Same journal

A review of the randomized clinical trial results from the Staphylococcus aureus network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa.

The Journal of antimicrobial chemotherapy·2026
Same journal

Incidence and factors associated with subtherapeutic cefazolin levels among patients with severe infections.

The Journal of antimicrobial chemotherapy·2026
Same journal

Emerging resistance in staphylococci following long-term dalbavancin treatment for prosthetic joint infections.

The Journal of antimicrobial chemotherapy·2026
Same journal

Microbiology testing around the time of antibiotic initiation among residents of long-term care facilities.

The Journal of antimicrobial chemotherapy·2026
Same journal

Insights into the mechanisms underlying cell wall-active agents and gentamicin bactericidal synergism against Enterococcus faecalis.

The Journal of antimicrobial chemotherapy·2026
See all related articles

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • History of Science

Background:

  • Quinine, a cinchona alkaloid, was introduced to Europe in the 17th century.
  • Early 19th-century isolation of cinchona alkaloids spurred synthesis efforts.
  • William Perkin's accidental discovery of mauve purple, the first aniline dye, occurred during quinine synthesis attempts.

Observation:

  • Dyes found applications in histopathology and medical microbiology, enhancing Paul Ehrlich's work.
  • Early successes using dyes against trypanosomiasis and malaria encouraged the German dye industry.
  • Antimicrobial research by the dye industry led to significant discoveries.

Findings:

  • The pursuit of dye-based antimicrobials by the German dye industry was fruitful.

Related Experiment Videos

  • Gerhard Domagk discovered the sulfa drugs (sulphonamides) in the mid-1930s.
  • This discovery stimulated further research in antimicrobial agents.

    • Implications:

    • The discovery of sulfa drugs marked a significant advancement in treating bacterial infections.
    • This breakthrough likely influenced the subsequent development of antibiotics.
    • The historical trajectory highlights the serendipitous nature of scientific discovery in medicine.