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Increased thrombin-antithrombin III complexes after 1 h of physical exercise
T Herren1, P Bärtsch, A Haeberli
1Department of Medicine, University of Bern, Switzerland.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|December 1, 1992
Summary
Intense exercise, especially running, significantly elevates thrombin-antithrombin III (TAT) complexes, indicating thrombin generation linked to anaerobic metabolism. Platelet activation also occurs during high-intensity exercise.
Area of Science:
- Exercise Physiology
- Hemostasis and Thrombosis
Background:
- Previous studies showed increased thrombin-antithrombin III (TAT) complexes after a 100-km run, with unchanged fibrinopeptide A (FPA).
- This suggested antithrombin III neutralizes exercise-induced thrombin, preventing fibrin formation.
Purpose of the Study:
- To investigate the clinical relevance of thrombin generation during exercise.
- To compare the effects of exhaustive running, recreational jogging, and exhaustive cycling on hemostatic markers.
Main Methods:
- Plasma concentrations of prothrombin fragments F1 and F2, TAT, FPA, and beta-thromboglobulin were measured.
- Participants included 10 in exhaustive running, 10 in recreational jogging, and 8 in exhaustive cycling groups, each exercising for 1 hour.
Main Results:
- Prothrombin fragments F1 and F2, and TAT concentrations significantly increased in all groups.
- The most substantial TAT increase was observed in the exhaustive running group (P < 0.001).
- TAT concentration correlated strongly with lactate levels (r = 0.62, P < 0.001).
- FPA levels remained within normal ranges for all groups.
- Beta-thromboglobulin increased in both running and cycling groups.
Conclusions:
- Thrombin is generated during exercise, particularly when associated with anaerobic metabolism.
- Platelet activation is a feature of high-intensity exercise.
- The findings highlight the link between intense physical exertion, coagulation activation, and anaerobic metabolism.