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Related Experiment Videos

Evolution and isoforms of V-ATPase subunits.

J P Gogarten1, T Starke, H Kibak

  • 1Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269-3044.

The Journal of Experimental Biology
|November 1, 1992
PubMed
Summary

V-ATPases and F-ATPases, crucial for cellular energy, share an ancient common ancestor. Their evolutionary journey reveals conserved structures and gene duplication events predating life

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Area of Science:

  • Evolutionary biology
  • Molecular biology
  • Biochemistry

Background:

  • V-ATPases and F-ATPases (ATP synthases) exhibit remarkable structural conservation across all life forms.
  • These enzymes likely originated from a single ancestral enzyme present in the last common ancestor of all extant life.
  • The catalytic and non-catalytic subunits of V- and F-ATPases are paralogous, indicating evolution from a shared ancestral gene predating the last common ancestor.

Purpose of the Study:

  • To investigate the early evolution of ATPases, focusing on V- and F-ATPases.
  • To evaluate the evolutionary relationships between V- and F-ATPase subunits and flagellar assembly proteins.
  • To predict the quaternary structure of ancestral ATPases and analyze the evolution of V-ATPase isoforms in eukaryotes.

Main Methods:

Related Experiment Videos

  • Comparative sequence analysis of V- and F-ATPase subunits.
  • Phylogenetic analysis of gene duplication events across the tree of life.
  • Mapping of evolutionary events to reconstruct ancestral enzyme structures and isoform origins.

Main Results:

  • V- and F-ATPases evolved from a common ancestral enzyme, with gene duplication predating the last common ancestor.
  • Phylogenetic mapping predicts the likely quaternary structure of ancestral ATPases.
  • Analysis of V-ATPase isoforms in eukaryotes suggests tissue- and organelle-specific functions, with varying evolutionary origins.

Conclusions:

  • The fundamental structure of V- and F-ATPases is ancient and highly conserved.
  • Gene duplication events played a crucial role in the diversification of ATPases.
  • Understanding ATPase evolution provides insights into cellular function and adaptation across different life forms.