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Related Experiment Videos

V-ATPases in phagocytic cells.

S Grinstein1, A Nanda, G Lukacs

  • 1Division of Cell Biology Hospital for Sick Children, Toronto, Canada.

The Journal of Experimental Biology
|November 1, 1992
PubMed
Summary

Vacuolar ATPases (V-ATPases) in phagocytic cells regulate organelle acidity, crucial for cell functions. This review covers their presence, regulation, and importance in cellular processes.

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Area of Science:

  • Cell Biology
  • Molecular Physiology

Background:

  • Vacuolar ATPases (V-ATPases) are essential proton pumps.
  • They mediate organelle acidification in phagocytic cells, impacting cellular functions.
  • Emerging evidence suggests their role in cytoplasmic pH homeostasis.

Purpose of the Study:

  • To review the current understanding of V-ATPases in phagocytic cells.
  • To discuss their localization, regulation, and functional significance.

Main Methods:

  • Literature review of existing studies on V-ATPases.
  • Analysis of research on V-ATPase presence in plasmalemmal and organellar membranes.
  • Examination of V-ATPase activity regulation and functional implications.

Main Results:

  • V-ATPases are present in both plasmalemmal and organellar membranes of phagocytic cells.
  • Proton pump activity is regulated at these locations.
  • V-ATPases are vital for receptor recycling, protein processing, and microbial degradation.

Conclusions:

  • V-ATPases play a critical role in phagocytic cell function through organelle acidification.
  • Understanding V-ATPase regulation is key to comprehending cellular processes.
  • Further research is needed to fully elucidate their role in cytoplasmic pH homeostasis.

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