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Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
Structural properties of polyethylene glycol-polysorbate 80 mixture, a solid dispersion vehicle
K R Morris1, G T Knipp, A T Serajuddin
1Pharmaceutics R&D Department, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903.
Journal of Pharmaceutical Sciences
|December 1, 1992
Summary
Polyethylene glycol (PEG) and polysorbate 80 mixtures remain solid and retain PEG
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Physical Chemistry
Background:
- Polysorbate 80 is a liquid surfactant at room temperature.
- Polyethylene glycols (PEGs) are polymers with varying molecular weights.
- Solid dispersions are used to enhance the dissolution of poorly water-soluble drugs.
Purpose of the Study:
- To investigate the structural properties of polysorbate 80 and PEG mixtures.
- To determine the suitability of these mixtures as solid dispersion vehicles.
- To understand the interaction between polysorbate 80 and different molecular weights of PEGs.
Main Methods:
- Powder X-ray diffraction (XRD) was used to analyze crystal structures and d-spacings.
- Differential scanning calorimetry (DSC) was employed to study melting behavior and phase transitions.
- Mixtures with varying concentrations of polysorbate 80 (up to 75% w/w) and different PEGs (1000, 1450, 3350, 8000) were prepared and analyzed.
Main Results:
- PEG-polysorbate 80 mixtures remained solid even with high concentrations of polysorbate 80.
- XRD studies showed that PEG crystal structures (d-spacings) were preserved, with peak intensities correlating to PEG concentration.
- DSC revealed minimal depression of PEG melting points (<12°C) and enthalpies of fusion similar to pure PEGs.
- Polysorbate 80 was found to be incorporated into the amorphous regions of the PEG solid structure.
Conclusions:
- PEG-polysorbate 80 mixtures maintain the crystalline integrity of PEG.
- Polysorbate 80 acts as a plasticizer within the amorphous phase of the PEG matrix.
- These solid mixtures are promising vehicles for formulating poorly water-soluble drugs due to their preserved structural properties.
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